effects of PGE1 and indomethacin on orthodontic tooth movement in rat

ABSTRACT

Prostaglandin E1 [PGE1] and indomethacin, a nonstroidal antiinflammatory drug, were separately administered during orthodontic tooth movement in rats. At the beginning, an orthodontic appliance was placed and activated in male albinus rats. In the first examination, the experimental group received submucosal injections of PGE1 [10 mg/kg/day] near the first maxillary right molars, and alcohol was injected to control group animals as a vehicle similarly. In the second examination, indomethacin [10 mg/kg/day] and methyl cellulose subcutaneously injected to experimental and control groups respectively. Tooth movement was measured at 1,3,5,7,9 and 11 days. In PGE1 group, tooth movement increased significantly at the beginning of seven days as compared to the vehicle injected group and the number of osteoclast and Howship's lacunae were markedly increased. A significant inhibition of tooth movement occurred beginning at seven days in the indomethacin group compared to the control group