Role of recombinant interleukin-12 as an adjuvant on vaccine-induced immunity in murine schistosoma mansoni infection
Journal of the Egyptian Society of Parasitology. 1999; 29 (1): 1-11
Dans Anglais
| IMEMR
| ID: emr-51115
ABSTRACT
In the present work, the role of recombinant interleukin-12 [rIL-12] as an adjuvant to soluble worm antigen preparation [SWAP] in protection against primary murine S. mansoni infection, using certain immunization protocol, was studied. A highly significant statistical increase in resistance [P <0.001] was observed in the group immunized with SWAP and rIL-12 [group I] and those immunized with SWAP only [group II] when each was compared to the infected control group [group III]. Moreover, resistance to challenge infection was higher in group I [73.6%] than in group II [66.1%]. In comparison to group III, histopathological examination of liver sections of groups I and II showed marked reduction in granuloma sizes with more reduction in group I to the extent that some ova were seen without cellular reaction around them. Liver necrosis and fibrosis were detected only in the infected control group
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Indice:
Méditerranée orientale
Sujet Principal:
Immunisation
/
Interleukine-12
/
Immunité
/
Souris
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. Egypt. Soc. Parasitol.
Année:
1999
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