study on the potential role of trichomonas vaginalis in transmission of hearpes simplex virus type ll

ABSTRACT

The present model was established for studying the ability of T. vaginalis to acquire herpes simplex virus type II [HSV]. Green monkey kidney cells [Vero cells] were infected with HCV and T. vaginalis was inoculated three days later. The progress of virus transmission was monitored by transmission electron microscopy [TEM]. Fragments of virus containing Vero cells were engulfed by the trichomonads and internalized in vacuoles, followed by resolution of the vacuole boundary. Viral particles aggregates were retained. Viable HSV was recovered from the trichomonads for five days. A study was conducted through cytopathological examination of 170 cervicovaginal smears The study revealed 25.8% having trichomoniasis, 2.9% HSV infection and 1.17% with combined infection; while HSV infections represented 4.5% in those having trichomoniasis. These results suggested the potential role of T. vaginalis in viral transmission to reduce this risk