Effect of nifedipine on creatinine clearance and urinary proteins in renovascular hypertension

ABSTRACT

Hypertension and impaired renal functions are closely interrelated. Elevated blood pressure can cause renal damage and renal diseases can cause hypertension. Hence, to evaluate the effect of Nifedipine on renal function in a hypertensive patient, a study was planned which extending over a period of three months. Fortyfive patients of either sex, aged 25-75 years were given Nifedipine 10 mg twice daily. Their urinary proteins and creatinine clearance were measured. Results were evaluated with base line values on Day 0, Day 30, Day 60 and Day 90. On Day 90, these two parameters were compared to base line [Day 0] values. With Nifedipine therapy, urinary protein reduction was 11.38 percent whereas creatinine clearance was increased to 13.15 percent. These changes in urinary proteins were highly significant whereas less significant in creatinine clearance with Nifedipine for three months, thus improving functions in renal impaired patients with hypertension