BCG dissemination in 40 patients and the review of leukocyte mycobacterium deffect in one patient

ABSTRACT

We have reviewed the medical records of 40 patients with disseminated [Bacille Calmette-Guerin] BCG from 1996 to 1999 in the Immunology Department of the Children Hospital, Medical Center, Tehran University. These patients are divided in to 3 groups 1. patients who had disseminated [Bacille Calmette-Guerin] BCG after vaccination and their diagnosis was chronic granulomatous disease. 2. Patients who had disseminated [Bacille Calmette-Guerin] BCG and were diagnosed as having cell mediated immunodeficiency. 3. patients whose Nitroblue Tetrazulium and CMI were around normal, but they could not kill intracellular mycobacterium, because of confirmed deficiency of interferon-gamma receptor and IL[12] receptor. Interferon-gamma receptor or CD119 was checked in 6 patients. In one patient interferon-gamma receptor deficiency was confirmed by flowcytometric analysis. In other patients, this marker was around normal, but presumably they had IL[12] receptor deficiency, which we were unable to detect in our laboratory. In some patients this marker should be checked after preparation of more laboratory facilities