Two weeks triple therapy with lansoprazole, amoxycillin and roxythromycin is better than dual therapy with lansoprazole and amoxycillin for h. pylori infection a randomised, clinical trial

ABSTRACT

AIMS: To compare the efficacy of 2 weeks of dual therapy of Lansoprazole and Amoxycilline with triple therapy of Lansoprazole, Amoxycilline and Roxythromycin for H. pylori eradication. SUBJECTS: Twenty-five suffering from dyspepsia and found H. pylori positive [CLO] during upper GI endoscopy. METHODS: Patients were divided into 2 groups, one group received Lansoprazole [30 mg] once a day, and amoxycilline [500 mg] three times a day [group I], while the second group received Lansoparazole and amoxycillin in similar dosage with the addition of Roxythromycin [150 mg] twice a day [group II]. H. pylori status was confirmed on endoscopy using CLO test at entry to the protocol and then at 4 weeks. H. pylori eradication was 57% in group I and 86% in group II with healing of lesions in all cases. Better response with triple therapy [group II] indicates enhanced eradication of the pathogens with triple therapy while using roxythromycin [JPMA 50157, 2000]