Immunohistochemical detection of the c-erb B-2 oncogene and the p53 tumor supressor gene in malignant and non malignant breast lesions and their prognostic significance

ABSTRACT

In a series of 50 breast lesions [31 malignant breast lesions and 19 benign breast lesions], expression of p53 protein and overexpression of c-erb B-2 oncoprotein were examined immunohistochemically. Expression of p53 was present in 17 out of 31 malignant cases. Five cases were infiltrated duct carcinoma grade II [IDC GII], nine cases were infiltrated duct carcinoma grade III [IDC GIII], two cases were mucoid carcinoma and one case was squamous cell carcinoma. No expression of p53 in invasive lobular carcinoma [ILC] was detected