Antitumour and antiinflammatory activities of hydroxamic acids and hydroxyurea

Antitumour activity has been evaluated using aceto [AHA], benzo [BHA], salicyl [SHA] cloroaceto [CHA], hydroxamic acids and hydroxyurea [HU] against Ehrlich ascites carcinoma [EAC] cells in Swiss albino mice. Anti-inflammatory activity of these compounds has also been studied in Sprague Dawley rats. Among these compounds only. CHA shows both antitumour and anti-inflammatory activities significantly. Although HU possesses highly effective antitumour activity, it does not show anti-inflammatory activity at all. Other compounds show differential antitumour and anti-inflammatory activities