Spectrophotometric determination of aminoglutethimide in pure form, in its tablets and in plasma

ABSTRACT

Simple, rapid and accurate spectrophotometric method for the assay of aminoglutethimide [AG] was described. This method is based on the formation of a highly colored stable radical anion complex between the drug as an n-electron donor and chloranilic acid [CLA] as a p-electron acceptor. The spectra of the complex showed a maximum absorbance at about 728 nm. Beer's law was obeyed in the concentration range of 0.15-0.5 mg ml-1. The proposed method was applied successfully for the determination of aminoglutethimide in pure form, in its tablets and in plasma. The results were favorably comparable to the official method: