Three different techniques for the analysis of chlordesmethyldiazepam

ABSTRACT

Three simple, rapid and accurate different techniques have been developed for the determination of chlordesmethyldiazepam. The first one depends on the spectrophotometric determination of the orange azodye resulting from the coupling of thymol with the acid-induced hydrolysis product of chlordesmethyldiazepam after conversion to the corresponding diazonium salt in alkaline medium. The second is the application of quantitative densitometry for the determination of chlordesmethyldiazepam in the presence of its degradation benzophenone product. While, the third technique implies HPLC resolution efficiency in the determination of chlordesmethyldiazepam in the determination of chlordesmethyldiazepam in the presence of its degradation benzophenone product