Treatment results of neo-adjuvant chemotherapy in advanced laryngeal carcinoma in upper Egypt

ABSTRACT

This study was carried out on eligible, previously untreated patients with local and advanced laryngeal carcinoma. A maximum of three cycles of chemotherapy was given, followed by local treatment according to the degree of response. This study included 31 eligible patients. Stage III disease was reported in 52% of the cases and stage IV reported in 48%. The assessment after neoadjuvant chemotherapy showed an overall response in 65% of the patients, a complete response [CR] in 23% and a partial response [PR] in 42%. Stable disease [SD] was found in 19% and progressive disease [PD] in 16%. Six patients underwent post-chemotherapy total laryngectomy and 20 patients had radical radiotherapy. After the completion of local treatment, CR was reported in 20 out of the 26 patients and PR in 6 patients. The preservation of larynx was achieved in 20 patients of the whole studied group. The disease free period [DFP] was significantly affected by the primary response to chemotherapy and tumor stage. The overall survival [OS] was not significantly detected by chemotherapy or method of local treatment