Benificial effect of administration of green tea with celecoxib

ABSTRACT

This study was conducted on rats to investigate the anti-inflammatory and ulcerogenic effects of four-day administration of green tea and its beneficial co-administration with celecoxib, a COX-2 inhibitor. The oral administration of green tea [20 and 40 mg/kg] exhibited a significant anti-inflammatory activity in carrageenan induced paw edema model; however, this effect was less than that evoked by celecoxib [25 mg/kg] which produced an anti-inflammatory activity superior to that of indomethacin [5 mg/kg] as a reference drug. The administration of celecoxib [25 mg/kg] with green tea [20 or 40 mg/kg] enhanced its anti-inflammatory activity. Green tea at both doses significantly inhibited plasma prostaglandin E2 [PGE2] level, but to an extent less than that produced by either celecoxib or indomethacin. The combined administration of green tea and celecoxib normalized plasma PGQ level. Green tea [20 and 40 mg/kg] exhibited a very weak ulcerogenicity [UI is 1.71 and 3.28, respectively] compared with that of celecoxib [UI is 10.43], which exhibited an ulcerogenic effect much less than that of indomethacin [UI is 21.6]. The combined administration of green tea [20 and 40 mg/kg] and celecoxib reduced the ulcerogenicity of celecoxib [UI is 8.37 and 8.84, respectively]. Moreover, serum urea nitrogen and creatinine levels were significantly increased after treatment with celecoxib, but to a less degree than that of indomethacin. The combined administration of green tea [20 and 40 mg/kg] significantly antagonized this effect and normalized urea nitrogen and creatinine levels