Potential protective effect of L-Arginine on cyclosporine A induced osteopenia in adult albino rats
New Egyptian Journal of Medicine [The]. 2002; 26 (6): 276-283
Dans Anglais
| IMEMR
| ID: emr-60226
ABSTRACT
This study aimed to assess the possible toxic effect of cyclosporine A [CsA] on bone and the potential protective effect of L-arginine on CsA-induced osteopenia. The study was conducted on 120 adult male albino rats divided into eight equal groups Group I [negative control], group II [distilled water], group III [corn oil], group IV [L-arginine, low dose], group V [L-arginine, high dose], group VI [CsA], group VII [L-arginine, low dose + CsA] and group VIII [L- arginine, high dose + CsA]. The duration of the study was six weeks, then the level of urinary deoxypyridinoline [Dpd] and N- terminal telopeptide [NTx] [markers of bone resorption], serum calcium, osteocalcin and bone specific alkaline phosphatase [BSALP] [markers of bone formation] were measured. Also, bone mineral density [BMD] of spine using dual energy X-ray absorptiometry [DEXA] was measured. The results showed that CsA had an osteopenic effect and L-arginine provoked a significant protective effect
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Indice:
Méditerranée orientale
Sujet Principal:
Arginine
/
Rats
/
Maladies osseuses métaboliques
/
Résorption osseuse
/
Densité osseuse
/
Agents protecteurs
/
Immunosuppresseurs
/
Monoxyde d'azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
New Egypt. J. Med.
Année:
2002
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