Protein c as an earlier diagnostic marker for some coronary heart disease

ABSTRACT

This work aimed to evaluate the role of protein C, some of the coagulation cascade proteins and lipids profile in ischemic heart disease [IHD] and myocardial infarction [MI]. The present study included 40 men selected from ICU Matareya Educational Hospital and classified into 20 cases suffering from ischemic heart disease [IHD group], 20 patients suffering from myocardial infarction [MI group] and a control group comprising 20 healthy normal males. Prothrombin time [IT] prothrombin [P] concentration, activated partial thromboplastin time [APTT], plasma fibrinogen concentration [PF] and protein C [PC] activity were measured in plasma. In serum, creatine kinase [CK], creatine kinase-MB [CK-MB], lactate dehydrogenase [LDH] activities, total lipids [T lipids], phospholipids, triacylglycerol [TAG], total cholesterol [TC], cholesterol-low density lipoprotein [LDL-C] and cholesterol-high density lipoprotein [HDL-C] were measured. The results of the study showed a positive relationship between the levels of plasma clotting factors and hyperlipidemic status, where there may be an interaction between plasma lipoproteins and procoagulant factors. Also, the hypothesis that MoL-C downregulates the thrombin generation via the PC pathway was supported