Assessment of multiple etiological and prognostic parameters in pre-eclampsia

ABSTRACT

Pre-eclampsia is an important cause of fetomaternal morbidity and mortality. It is not only unpredictable in onset and progression, but also has no effective management strategy except termination of pregnancy. There are many factors lying behind the pathogenesis of the disease. We sought at measuring different parameters as etiological and prognostic factors in pre-eclampsia. Lipoprotein [a], P-selectin, prothrombin fragment 1+2 and thrombin anti-thrombin complex were measure and correlated with the severity of the disease. We found that those parameters are increased in pre-eclamptic patients and most of them correlated with the degree of pre-eclampsia. We suggest an etiological and prognostic significance in the course of pre-eclampsia