Histological changes in renalvessels of albino rats fed on canola oil and hyperlipidaemic diet

ABSTRACT

To evaluate and compare the atheroscIerotic changes with intake of dietary monounsaturated fatty acid [canola oil] and hyperlipidaemic diet on the renal arteries of albino rats. Design: It was an experimental study conducted at Postgraduate Medical lnstitute [PGMI] Lahore for 24 weeks. Materials and Methods Sixty albino rats of 8 weeks age, equal number of males and females were divide in to five groups of 12 animals each.[Group DO-4]. Different diets were prepared and given to the animals for 24 weeks. Renal arteries were taken to see changes. Gross and microscopic changes for atherosclerosis were studied in animals sacrificed after one week [Group DO] and in animals scarified after 24 weeks of experiment [Groups 1-4]. Only one animal showed atherotic lesion in-group D 2, while all other animals remained lesion free. Our study proved that canola oil was one of the beneficial diets. Canola oil was not only effective when used alone in the diet but it also protected and prevented the atherosclerotic changes of other atherogenic diets