Effect of p-CPA pretreatment on EEG power spectra in experimental open brain injury in rats

ABSTRACT

Continuous four hours EEG [electroencephalogram] recordings and its power spectrum analysis using fast fourier transform [FFT] in urethane anesthetized male Charles Foster rats were performed in two groups open brain injury and p-CPA [para-Chlorophenylalanine] pretreated before brain injury, respectively, and compared with the EEG power spectrum of control rats. The EEG power spectrum analysis showed that there was a faster recovery in p-CPA pretreated group than the injury group of rats. The results showed that the p-CPA [a 5-HT inhibitor] prevents pathological changes following brain injury. Simultaneously, the inference can also be drawn that EEG power spectrum analysis is a useful technique for monitoring the brain injury and its recovery following pharmacological treatments