Cellular and humoral immune responses to recombinant Smp17.7 Schistosoma mansoni antigen
Journal of the Egyptian Society of Parasitology. 2003; 33 (3): 925-946
Dans Anglais
| IMEMR
| ID: emr-62894
ABSTRACT
To determine the immunological responses to S. Mansoni antigen rSmp 17.7, a total of 184 subjects [174 patients from a schistosomiasis endemic area and 10 controls] was used. Proliferation, cytokine profile in culture supernatants from antigen-stimulated peripheral blood mononuclear cells and specific IgG1, IgG3, IgG4, IgA, IgM and IgE levels were assessed. The highest stimulation index to rSmp 17.7 was detected in S. mansoni patients. The evaluation of the cytokine profile [IL-2, IL-4 and IFN-gamma] in response to this antigen showed a significant increase as demonstrated by enzyme linked immunosorbent assay [ELISA]. Specifically, IFN-gamma and IL-2 were significantly detected by flow cytometry. IgG1 and IgM were significantly increased. These results highlighted the importance of rSmp 17.7 as a candidate vaccine for schistosomiasis. The results facilitate to understand the mechanism of schistosome vaccine efficacy
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Indice:
Méditerranée orientale
Sujet Principal:
Praziquantel
/
Schistosoma mansoni
/
Immunoglobuline A
/
Immunoglobuline E
/
Immunoglobuline G
/
Immunoglobuline M
/
Interleukine-4
/
Interféron gamma
/
Interleukine-2
/
Immunité cellulaire
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
J. Egypt. Soc. Parasitol.
Année:
2003
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