Interleukin-6 and its relationship with the complications of diabetes millitus

ABSTRACT

Diabetes mellitus is a complex disease with multiple complications which classified to two categories Acute complications Hypoglycemia, diabetic ketoacidosis [D.K.A] and hyperglycemic hyperosmolar non ketonic syndrome [H.H.N.K]. Chronic complications Macrovascular complications, Microvascular complications, diabetic Retinopathy, diabetic Nephropathy and diabetic Neuropathy. We evaluated the relationship of proinflanimatory cytokines [IL-6] with microvascular complications of diabetes mellitus. The first group included [31] diabetic nephropathy patients [dialysis patients]. The second group included [67] diabetic patients with retinopathy. The third group included [57] diabetic patients with neuropathy. The three groups compared with control group included [21] healthy subjects absence of any systemic diseases and infections, matched for sex and age. Our results showed significant increase in both mean plasma glucose and [[p<0.05]. The renal patients group were compared with control group and the correlation between high [LL-6] levels and incidence of nephropathy was significant. The second group showed significant increase in the mean plasma [IL-6] levels [p<0.05]. x test showed significant correlation between the serum [IL-6] levels in the patients and incidence of retinopathy. Whereas in the third group, our study showed no significant differences in levels of [IL-6] compared with control group [p>0.05] and no correlation between the serum [LL-6] and incidence of Neuropathy