Hepatoprotection by Jigrine, a Unani herbal formulation, during country-made liquor-induced hepatotoxicity in rats

ABSTRACT

The hepatoprotective potential of Jigrine tablets [a Unani polyherbal formulation containing a mixture of 14 medicinal plants] was evaluated in country-made liquor [CML]-induced hepatotoxicity in Wistar rats. The rats were made hepatotoxic by administering CML [3 ml/100 g/day in 2 divided doses] and corn oil [1 ml/100 g/day, in a single dose] orally for 21 days. The administration of Jigrine [200 mg/kg and 400 mg/kg] orally from day 15 to day 21 along with CML produced significant lowering [p<0.01] of serum AST, ALT, ALP, gamma-GTP and tissue lipid peroxide levels. The results were comparable to silymarin [25 mg/kg, orally]. The study shows that the Jigrine is definitely a hepatoprotective agent and reduction of liver damage by Jigrine treatment involved several mechanisms