Macrophage inflammatory protein 1 - alpha [MIP -I]: its pathogenetic role in some connective tissue diseases

ABSTRACT

This study aimed to measure serum level of macrophage inflammatory protein 1- alpha [MIP-la] in some connective tissue diseases as rheumatoid arthritis [RA], systemic lupus erythematosus [SLE] and systemic sclerosis [SSc] in order to clarify its possible role in their immunopathogenesis. Fifteen RA patients [group I], 15 SLE patients [group II], 10 SSc patients [group III] and 10 healthy controls [group IV] were participated in this study. A full history taking, thorough clinical examination and routine rheumatological profile investigations were done. Serum MIP-1-alpha was measured in all patients and control groups using ELISA technique. In conclusion, the higher level of serum MIP-1-alpha in RA, SLE and SSc patients could reflect its immunopathogenetic role as an important stimulator of T cells, monocyte macrophage as well as its variable pro-inflammatory activates