Combination of fluoxetine and nortriptyline in the treatment of obsessive compulsive disorders
MJIH-Medical Journal of the Iranian Hospital. 2004; 6 (2): 16-20
Dans Anglais
| IMEMR
| ID: emr-67782
ABSTRACT
There is growing interest in investigating noradrenergic functions in Obsessive Compulsive Disorder [OCD] because some antidepressants with strong effects of serotonin reuptake inhibition fail to relieve obsessive-compulsive symptoms. We undertook a trial to investigate whether the combination of fluoxetine with nortriptyline is more effective than fluoxetine alone. Thirty nine patients who met the DSM-IV criterias for OCD were included in the study. Patients were allocated in a random fashion, 19 patients to fluoxetine 40mg/day plus nortriptyline 40mg/day and 20 patients to fluoxetine 40mg/day plus placebo. Although both protocols significantly decreased the scores of the Yale-Brown obsessive-compulsive scale over the trial period, the combination of fluoxetine and nortriptyline showed a significant superiority over fluoxetine alone in the treatment of OCD. As this study indicates, a rapid onset of action is one of the advantages of this combination. This study supports further investigation of the noradrenergic-serotoninergic hypothesis in OCD
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Fluoxétine
/
Association thérapeutique
/
Association de médicaments
/
Nortriptyline
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Med. J. Iran. Hosp.
Année:
2004
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