Hydrocortisone effects on composition of rat bone
Egyptian Journal of Biophysics and Biomedical Engineering. 2005; 6 (2): 105-117
Dans Anglais
| IMEMR
| ID: emr-70529
ABSTRACT
Hydrocortisone is sometimes used as a necessary treatment for many diseases. But unfortunately, it usually causes osteoporosis when used for long periods of administration even with normal doses. It produces variations in calcium and phosphate contents in bones. The aim of the present work is to study the effects of long period hydrocortisone treatment on the bone composition of rat hind-leg. Three techniques were used in this study X-ray imaging to analyze the bone density, molecular spectrophotometer for determining bone composition and histological study to clear the bone structure. The obtained data showed variations in calcium and phosphate contents during the hydrocortisone treatment periods which reached maximum changes after three weeks of treatment. The obtained results by X-ray images indicated changes in the bone density which were supported and found in good agreement with that obtained by both spectrophotometric analysis and structural changes
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Indice:
Méditerranée orientale
Sujet Principal:
Ostéoporose
/
Phosphore
/
Rats
/
Os et tissu osseux
/
Densité osseuse
/
Calcium
/
Jambe
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Egypt. J. Biophys. Biomed. Eng.
Année:
2005
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