In vitro effect of nystatin, gentian violet and garlic extract on candida albicans isolates from oral cavity

ABSTRACT

To evaluate in-vitro anticandidal activity of Nystatin. Gentian Violet and Garlic extract on Candida albicans isolates from oral cavity. For screening of antifungal activity of Nystatin. Gentian Violet and Garlic Extract, 100 clinical isolates were collected from the department of Radiotherapy. Jinnah Postgraduate Medical Center and Fatima Jinnah Dental College and Hospital, Karachi. The samples were collected from the oral cavity and the sample site was buccal mucosa, tongue and hard palate. These isolates were finally identified on the basis of morphology and cultural characteristics and confirmed using germ tube method. The antifungal activity of Nystatin, Gentian Violet and Garlic Extract were carried out by disc diffusion method. Result showed that the mean zone of inhibition of Nystatin was 17.9mm, Gentian violet was 16.6mm and Garlic Extract was 16.6mm and all the drugs used were found to be very effective. It can be concluded from the study that all the drugs are very effective against clinical isolates of Candida albicans and secondly the organism had not developed any resistance to these drugs