Effects of thiopental/methoxyflurane and thiopental/halothane on blood pattern, acid-base status, electrocardiogram and respiration of oxytetracycline treated experimental animals during prolonged surgical anesthesia

ABSTRACT

Oxytetracycline alone did not produce clinically significant changes in the blood patterns and electrocardiograms of the animals. In animals pretreated with oxytetracycline, thiopental /methoxyflurane produced significant lymphocytopenia and neutrophilia. These charges were in contrast with the lymphocytosis and neutropenia observed during the period of oxytetracycline treatment. Hematocrit and Hb. concentration both declined during oxytetracycline treatment and were aggravated in thiopental/methoxyflurane and thiopental/halothane anesthetized animals. A significant increase was observed in the clotting time of thiopental/ halothane anesthetized animals, which corresponded to a decrease in prothrombin time. Fifty percent of oxytetracycline pretreated animals showed periodic Cheyne-Stokes respiration during thiopental/halothane anesthesia, while this phenomena was observed less in the thiopental/halothane anesthetized group which had not received oxytetracycline. Plasma P[v] CO[2] increased significantly in both thiopental/methoxyflurane and thiopental/halothane anesthetized animals. The increase corresponded to a significant decrease in plasma. pH. The plasma pH seemed slightly ameliorated with normal physiological responses