Alpha blocker therapy for the treatment of idiopathic oligozoospermia

ABSTRACT

To evaluate the efficacy of an alpha-blocker [prazosin] for the treatment of idiopathic oligozoospermia. The study group included 18 infertile men aged 26 to 45 years [with mean age of 35 years] with sperm densities between to 20 x 10[6] sperm/ml, normal serum gonadotropins, testosterone, and prolactin level. Patients were prescribed prazosin - 2mg/d for six months. Semen samples were collected before and three months and six months after therapy. Semen parameters were evaluated before and after the treatment. The Pregnancy Rate [PR] was 27.7%. There were a significant increase in sperm concentration and total-motile sperm count. It appears that an alpha-blocker [prazosin] is a useful drug in the treatment of idiopathic oligospermic males