Comparison of fentanyl / isoflurane versus nalbuphine/isoflurane in patients undergoing elective coronary artery bypass surgery

ABSTRACT

To compare hemodynamic stability, efficacy and extubation time by using fentanyl / isoflurane versus nalbuphine / Isoflurane for coronary artery bypass surgery. Intervention experimental study. The Department of Anesthesiology and Surgical Intensive Care Unit, Dow Medical College and Civil Hospital, Karachi from April 2003 to April 2004. Sixty patients, both sexes, with ejection fraction not less than 40%, elective coronary artery bypass surgery were randomly allocated to receive either fentanyl / isoflurane or albuphine. Hemodynamic stability, drugs supplemented and extubation time were recorded. During intubation, skin incision and sternotomy systolic blood pressure was 126, 47 +/- 7.45, 127.97 +/- 7.58 and 127.03 +/- 7. 10 in group A fentanyl/isoflurane] and 167.60 +/- 14.41, 169.50 +/- 12.99 and 165.83 +/- 11.79 in group B nalbuphine/isoflurane] respectively with [p < 0.05] which is significant. To maintain hemodynamic stability in group B, supplementation with propofol and glyceryltrinitrate infusion was required. Extubation time in group A was 8.2113.87, and in group B was 6.15 +/- 3.41 with [p<0.05] which is significant. Fentanyl/isoflurane provides better hemodynamic stability than nalbuphine / isoflurane, but nalbuphme / isoflurane leads to earlier tracheal extubation than fentanyl / isoflurane group