Diabetic nephropathy with inflammatory indicators [IL-1B, IL-6, IL-8, CRP]

ABSTRACT

cytokines production is associated with diabetes mellitus and in its turn is associated with infiltration of the islets of Langerhans with autoreactive lymphocytes and specific destruction of the insulin-producing B cells. Our aim is therefore to investigate the effect potential role of the effect of the cytokine especially [interleukin-lB, interleukin-6, interleukin-8] and C-reactive protein [C.R.P.] on the microvascular complications of diabetes [nephropathy]. A total of 31 diabetic patients with nephropathy aged 45 to 60 years, undergoing dialysis were compared with non-diabetic control subjects [N=20] after matching for age and sex, and were compared also with diabetic subjects without nephropathy [N=124]. Immune parameters were analyzed in serum with rigidly evaluated ELISA. Serum proinflammatory interleukin-6 [IL-6] and interleukin-8 [IL-8] concentrations were higher in nephropathy diabetic patients than in the control subjects [Mean for IL-6 in nephropathy and control subjects 6.9 Pg/ml, 1.2 Pg/ml respectively P