Time course of changes in passive aviodance and y-maze performance in male diabetic rats
IBJ-Iranian Biomedical Journal. 2006; 10 (2): 99-104
Dans Anglais
| IMEMR
| ID: emr-76720
ABSTRACT
Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and Y-maze performance in male diabetic rats. For this purpose, male Wistar rats were randomly divided into control and diabetic groups. For induction of diabetes, streptozotocin [STZ] was injected i.p. at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency [IL] and step-through latency [STL] were determined at the end of 1[st], 2[nd], and 3[rd] months using passive avoidance and Y-maze tasks. It was found out that mean IL exhibits a significant increase only at the end of 2[nd] [p<0.05] and 3[rd] [p<0.01] months. In addition, STL significantly reduced at the end of 2[nd] [p<0.05] and 3[rd] months [p<0.01]. Regarding Y-maze task, alternation score of the diabetic rats was lower than that of the control ones at the end of 1[st] [p<0.05], 2[nd] [p<0.01], and 3[rd] [p<0.01] months as compared to time-matched control group. To conclude, at least one month is strictly required for development of behavioral disturbances in passive avoidance and Y-maze tasks in STZ-diabetic rats
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Rat Wistar
/
Cognition
/
Apprentissage du labyrinthe
/
Diabète expérimental
/
Mémoire
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Iran. Biomed. J.
Année:
2006
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