8 hydroxydeoxyguanosine levels: periodontitis in smoker and non smoker: a pilot study

ABSTRACT

To determine the association between levels of a marker of oxidative stress, 8- hydroxydeoxyguanosine [8-OHdG], in saliva and presence of periodontitis in smokers and non-smokers. Forty subject samples, as healthy control [n=16], periodontitis in smokers [n=11] and periodontitis in non-smokers [n=13] were recruited for the study. The 8-OHdG were analyzed in the saliva of smoking and non-smoking patients of periodontitis and healthy control. Salivary levels of 8-OHdG were significantly higher in subject with periodontitis who smoked as compared to non-smoker [6.82 + 0.18 ng/ml and 4.83 + 0.16 ng/ml]. Thus, measurement of 8-OHdG may prove to be useful in identifying periodontal disease and risk of tooth loss