Association of leukocyte count with albumin excretion in type 2 diabetes mellitus

ABSTRACT

In type 2 diabetes Mellitus albumin excretion rate correlates with leukocyte count. One of the major components of chronic sub clinical inflammation associated with both insulin resistance and other sclerosis. The aim of this study was to determine the relationship between leukocyte count and Albumin excretion in patients with type 2 diabetes Mellitus. A prospective study conducted on patients with type 2 diabetes during 2004 at BMSI Jinnah Post graduate Medical Centre Karachi. A total of 100 subjects of either sex were included, out of which 75 type 2 diabetics were selected from diabetic clinic Jinnah post graduate Medical Centre Karachi and 25 non diabetics as control from general population. Each subject was interviewed, examined and investigated for blood pressure measurements, body weight, fasting serum glucose urinary volume, urinary albumin, albumin creatinine ratio, urinary albumin excretion and leukocyte count. Patients having acute illness and proteinuria due to cardio vascular disease and other causes were excluded. Leukocyte count was significantly high [P<0.001] in all patient groups as compared to control group, also it shows significant increase in smoker diabetics as compared to non smoker diabetics. A strong relation ship was found between leukocyte count and albumin excretion r =0.786, P< 0.001 in type 2 diabetes Mellitus. Albumin excretion rate correlates with leukocyte count in patients with type 2 diabetes Mellitus