Comparative study between effect of aromatase inhibitor and clomiphene citrate in gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility
Medical Journal of Cairo University [The]. 2006; 74 (1): 99-104
Dans Anglais
| IMEMR
| ID: emr-79167
ABSTRACT
To compare the effects of aromatase inhibitor, letrozole and clomiphene citrate [CC] in gonadotrophin dose required for controlled ovarian stimulation [COS] in patients with unexplained infertility undergoing intra uterine insemination [IUI]. Non randomized prospective study. Al-Azhar University Hospital, Dammieta. Ninety patients with unexplained infertility undergoing COS and IUI. Thirty two women received letrozole in a dose of 2.5mg/day from day 3 to day 7 of the menstrual cycle + FSH, 18 women received CC in a dose of 100mg/day from day 3 to day 7 of the menstrual cycle + FSH and 40 women received FSH only as a control group. All patients were given highly purified FSH [75-150IU] starting of day 3 to day 7 until the day of hCG administration. Total FSH dose/cycle, number of mature ovarian follicles, estradiol [E2], lutenizing hormone [LH] levels, endometrial thickness, cervical mucus score at the day of hCG and pregnancy rate. The FSH dose was significantly lower in letrozole + FSH group and CC + FSH group when compared with FSH only group without a difference in number of follicles >/= l8mm. E2 levels were significantly lower in the letrozole + FSH group compared with the other two groups. Cervical mucus score, endometrial thickness and pregnancy rate were significantly lower in CC + FSH group when compared with the other two groups. Similar to CC, aromatase inhibition with letrozole reduces FSH dose required for COS without the undesirable anti-estrogenic effects sometimes seen with CC
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Indice:
Méditerranée orientale
Sujet Principal:
Induction d'ovulation
/
Hormone lutéinisante
/
Études prospectives
/
Clomifène
/
Hormone folliculostimulante humaine
/
Inhibiteurs de l'aromatase
/
Oestradiol
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Med. J. Cairo Univ.
Année:
2006
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