Effect of haemofiltration in prevention of contrast induced nephropathy and on acid/base status in predialysis chronic kidney disease patients undergoing cardiac catheterization

ABSTRACT

High risk renal failure patients have increased risk for contrast nephropathy during coronary angiography despite the use of conventional prophylaxis with intravenous hydration and acetylcysteine. The aim of the study was assess the role of haemo filtration versus conventional prophylaxis in preservation of kidney function and prevention of contrast nephropathy in chronic kidney disease patients undergoing cardiac catheterisation. There was a highly significant reduction in BUN, creatinine, serum uric acid [p<0.001] in haemofiltration group in comparison with baseline and control group till day 4 that was not significant after one week. There was a significantly improving rise in pH and serum HCO[3] level in haemofiltration in haemofiltration group till 24 hours post contrast injection [p<0.001]. Haemofiltration can provide adequate pres ervation of kidney function in high risk renal patients under going cardiac catheterisation. It also achieved proper adjustment of acid/base status in such patients