Plasma osteopontin concentration in lupus nephritis
Egyptian Rheumatology and Rehabilitation. 2007; 34 (1-2): 225-238
Dans Anglais
| IMEMR
| ID: emr-82482
ABSTRACT
To measure plasma concentration of osteopontin and to correlate these levels with clinical, laboratory, disease activity and histopathological parameters in SLE patients. This study was performed on 20 SLE patients and 10 normal control subjects. Plasma osteopontin concentrations were measured by ELISA technique for both patients and control groups. All patients underwent renal biopsies within 3 months of onset of proteinuria or hematuria. There was a highly significant difference between patients and control groups as regards plasma osteopontin concentration [p<0.001]. There was a significant positive correlation between osteopontin and SLEDAI [p<0.001] and activity index of renal biopsies [p<0.05]. Also there was a highly significant differences as regard osteopontin plasma concentration between patients with and without renal affection [p<0.001]. Osteopontin has been shown at least partly to account for SLE nephritis probably through predominance of Th[1]-type response in both peripheral and renal tissue. Further investigation of this mechanism in lupus nephritis may allow the design of new therapeutic strategies of lupus nephritis such as manipulation of Th[1]/Th[2] and down-regulation of Th[1]-response
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Indice:
Méditerranée orientale
Sujet Principal:
Immunohistochimie
/
Évolution de la maladie
/
Ostéopontine
/
Histologie
/
Rein
/
Tests de la fonction rénale
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Egypt. Rheumatol. Rehabil.
Année:
2007
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