Possible association of HLA-DR and DQ molecules with colorectal cancer in Iraqi patients

ABSTRACT

Human leukocyte antigen [HLA] is the most polymorphic genetic system in man. The genes of this region influnence susceptibility to certain diseases. This study was established to shed light on the possible association of HLA class-II antigens and CRC patients, and to correlate the findings with both family history and tumor location. Microlymphocytotxicity assay has been used to assess HLA-typing of 150 blood samples of 100 CRC patients and 50 healthy normal control. An increased frequency of HLA-DR7 was observed for patients' group versus control group with P-value [<0.005], moreover, statistical analysis showed non significant correlation of HLA-DR7 with both family history of CRC and tumor location. This finding demonstrate that HLA-DR7 might play a role in CRC susceptibility