Development of a mathematical model for myoelectric activity of small intestine to reach a better understanding of the pathophysiology of Irritable bowel syndrome [I.B.S.]

ABSTRACT

Since enteric nervous system is a complicated network and calls for more investigations, we decided to develop a model for myoelectric activity of small intestine by use of artificial nerve networks, in order to reach a better underst and ing of I.B.S. According to empirical knowledge concerning I.B.S, serotonin level in enteric nervous system increases and this system becomes more excitable and active. The aim of this study was to prove these issues by use of mathematical models. MTLAB 6.5 soft ware was used in this project. Artificial nerve networks, equivalent to enteric nervous system were designed. By making use of artificial nerve networks, amplitude, time and number of spikes in the myoelectric curve of small intestine were determined which were compatible with empirical information. Using artificial nerve networks, the effect of increased level of serotonin as a pathophysiological factor, on bowel movement in IBS was established. This study can pave the way for designing other artificial networks to assess potential effects of drugs; or developing more effective methods for treatment of I.B.S.