Hydantoia and thiohydantoia derivatives as potential antimicrobial agents: Part I

ABSTRACT

Several hydantoin and 2-thio analog derivatives have been prepared. Condensation of 3-methyl-2,4imidazolidine-dione [IA] with aromatic aldehydes afforded the corresponding arylidene derivatives. Coupling of 3-methyl-2-thioxo-4- imidazolidinone [IB] with diazonium salts yielded the expected 5-aryl- hydrazone derivatives. In addition, Mannich reaction of [IB] with formaldehyde and certain secondary amines gave the desired products. However, attempts to condense [IA] with formaldehyde and secondary amines under the Mannich conditions were abortive and the same hydantoin also failed to couple with aryl diazonium salts. Five compounds have been screened against selected bacteria and some of them were found to possess moderate to fairly good antibacterial activity