Effects of ovariectomy and thyroidectomy on course and outcome of Trichinella spiralis infection in rat
Journal of the Egyptian Society of Parasitology. 2008; 38 (1): 29-46
Dans Anglais
| IMEMR
| ID: emr-88248
ABSTRACT
Physiological hormones modulate immune responses and implicate in associated susceptibilities to infections. To clarify these endocrinological effects, the influence of estrogen and thyroid deficiency, due to ovariectomy and thyroidectomy, respectively, on course and outcome of Trichinella spiralis infection in rats was studied. While in ovariectomized rats there was significant increase in both adult and muscle larval counts as compared to intact infected rats, in thyroidectomized rats there was a significant increase in larval but not in adult count. Combined ovariectomy and thyroidectomy resulted in significant increase in both adult and larval counts. Serum CPK and blood glucose were significantly elevated in ovariectomized and/or thyroidectomized rats as compared to intact infected one. The deficiency of female sex hormones, and/or thyroid hormones in T. spiralis infected rats affected the host resistance to infection by increasing parasite burden influencing the course and outcome of parasitic infection
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Rats
/
Hormones sexuelles stéroïdiennes
/
Hormones thyroïdiennes
/
Thyroïdectomie
/
Glycémie
/
Ovariectomie
/
Trichinella spiralis
/
Creatine kinase
/
Modèles animaux
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. Egypt. Soc. Parasitol.
Année:
2008
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