gingival crevicular fluid leptin concentrations in pregnant women with periodontitis: a pilot study

ABSTRACT

Leptin, a pleiotropic cytokine, regulates various metabolic and endocrine responses, has emerged as an important regulator of inflammation. Also, hyperleptinemia has been reported as a component of metabolic syndrome. Association between periodontitis, pregnancy and cardiovascular risk has been suggested. Hence, the present study was planned to study gingival crevicular fluid [GCF] leptin concentrations in pregnant women with and without periodontitis. Twenty five pregnant women with periodontitis and 10 pregnant women as a control were recruited. Leptin [GCF] leptin concentrations were analyzed by competitive ELISAkit. The leptin levels were significantly lower in pregnancy periodontitis patients as compared to normal pregnant women [p<0.01]. The higher leptin GCF levels in pregnant women without periodontitis may have a protective role in periodontal disease. Further studies are required to clarify role of GCF leptin, and the possibility of leptin receptors in gingiva and periodontal ligament in pathogenesis of periodontal disease in pregnancy and future cardiovascular risk