Serum level of cytokeratin 19 as a serum marker in preeclampsia

ABSTRACT

The cytokeratin family is expressed by all epithelial cells and it appears therefore to be a general specific and useful marker of epithelial differentiation. Cytokeratin 19 is over pressed in strongly proliferating tissues. Excessive proliferation of immature trophoblasts within the placenta might contribute to an increase in the serum cytokeratins in women with preeclampsia. To evaluate cytokeratin 19 as a serum marker of preeclampsia. This prospective study included sixty nine primigravida who attended the outpatient clinic of Obstetrics and Gynecology Minoufiya University hospital in the period from October 2006 to June 2007. Their ages were between [20-31] years, and their gestational ages were between [30-38] weeks, The patients were divided into two groups, group [A] 45 women with preeclampsia and group [B] 24controls. Serum cytokeratin 19 levels were measured in all patients using enzyme - linked immunosorbent assay [ELISA]. Cytokeratin 19 levels were identified with no statistical difference in the study groups regarding maternal age and mode of delivary [p > 0.05], while there was significant statistical difference regarding blood pressure and birth weight. The mean of serum cytokeratin 19 level in preeclampsia was significantly higher in women with preeclampsia than control group [p<0.001]. Significant positive correlation between blood pressure and serum level of cytokerati 19 in preeclamptic patients. Birth weight < 2000 gm was associated with higher level of cytokeratin 19. Cytokeratin 19 can be used as a marker for preeclampsia and disease severity