Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state

ABSTRACT

The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC [0-t] and AUC [0-inf] were significantly different between normal and dehydrated rabbits [P < 0.05], but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition