Comparison of effectiveness of two different premarin dose in hot flash treatment

ABSTRACT

Hot flush is the most common and severe problem of menopausal period. Estrogen is used for elimination of hot flush as an original and selective medicine. The objective was to determine the lowest useful dose because of estrogen's side effects. This clinical trial was done on 180 menopausal women who were complaining of hot flush. They were randomly divided in three groups. Group one took 0.3mg conjugated estrogen plus 1.25mg medroxyprogestronacetate, group two took 0.15mg conjugated estrogen plus 1.25mg medroxyprogestronacetate and group three took placebo for one month. Hot flush improvements in these three groups were defined. The average improvement was 78.5% with median 80 and mode 80 in group one [0.3 mg]. The average improvement was 63.3 percent with median 60 and mode 60 in group two [0.15mg]. The average improvement was 13.8% with median one and mode one in group three [placebo]. Due to average improvement of 63.3% in 0.15mg conjugated estrogen user group it is logical to begin hot flush treatment with this 0.15mg conjugated estrogen dose