Effect of compound 11 g as a novel selective cox-2 inhibitor on movement disorders in a rat model of parkinson's disease
Pakistan Journal of Medical Sciences. 2008; 24 (3): 436-441
Dans Anglais
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| ID: emr-89549
ABSTRACT
To test the effect of selective COX-2 inhibitors compound 11g on movement disorders of Parkinson's disease [PD]. In the study the rat Left substantia nigra pars compacta [SNc] has been destroyed using electrical Lesion [10 Sec; 1 mA DC] to generate PD model. Then 11g [2, 4mg/kg] and celecoxib a well known and standard COX-2 inhibitor [4, 8mg/kg] have been administrated orally to parkinsonian rats. Then the rigidity and locomotor activity of parkinsonian rats were evaluated. Both selective COX-2 inhibitors decreased the rigidity and improved the locomotor activity of parkinsonian rats P>O.05 as compared to the control groups. Based on the results of the locomotor activity and rigidity tests using parkinsonian rats, we found that compound 11g had remarkable rigidity-improving effect
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Indice:
Méditerranée orientale
Sujet Principal:
Maladie de Parkinson
/
Pyrazoles
/
Sulfonamides
/
Substantia nigra
/
Résultat thérapeutique
/
Modèles animaux
/
Électrotraumatisme
/
Troubles de la motricité
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Pak. J. Med. Sci.
Année:
2008
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