Serum lipid profile; correlation of nigella sativa and sunflower oil diet intake in albino rats

ABSTRACT

To determine the effects of Nigella sativa and sunflower oil diet intake on serum lipid profile in albino rats. Eighty four albino rats with equal number of males and females were selected for the study, they were divided into six different groups. Control groups1,111,V,were given low fat diet[3%], high fat diet[20%], high fat diet supplemented with bile salt [1% colic acid] and antithyroid drug [0.5% propylthiouracil]. The Experimental groups were given the above diets with supplemented Nigella sativa. Low fat diet increased all the lipid fractions significantly when given at12 and 24 weeks duration as compared to 0 week. The high fat diet when given at different intervals decreased all lipid fractions significantly as compared to baseline level. The high fat diet with propylthiouracil and bile salt also increased all the lipid fractions and the increase was more as compared to previous groups. The supplements of Nigella sativa in the groups decreased all the lipid fractions significantly as compared to the control groups except HDL-c, which was significantly increased in all the experimental groups as compared to control groups. On the basis of these findings conclusions are made, that Nigella sativa has got TG,TC, and LDL-c lowering and HDL-c raising effects.3% sunflower oil low fat diet has got TG,TC,HDL-c, and LDL-c raising effects.20% sunflower oil high fat diet has got TG,TC,HDL-c and LDL-c lowering effects. Both Nigella sativa and sunflower oil have got low atherogenic index [TC/HDL] and may be recommended in hyperlipidaemic patients or normal individuals