Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran
IJI-Iranian Journal of Immunology. 2009; 6 (1): 49-54
Dans Anglais
| IMEMR
| ID: emr-91227
ABSTRACT
HLA-B*27 is strongly associated with ankylosing spondylitis [AS]. It represents a family of alleles that differ among ethnic groups. The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan [Iran]. Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLA-B*27 subtypes were determined by PCR-SSP. Forty patients [66.7%] and 17 controls [3.95%] were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls. Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnic-group studies
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Indice:
Méditerranée orientale
Sujet Principal:
Pelvispondylite rhumatismale
/
Études cas-témoins
/
Réaction de polymérisation en chaîne
/
Allèles
/
Cytométrie en flux
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Iran. J. Immunol.
Année:
2009
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