Journal of Medicinal Plants. 2009; 8 (29): 51-57
Dans Persan
| IMEMR
| ID: emr-91799
ABSTRACT
Purtulaca pleracea [PO] overgrows in the different parts of Iran. In previous studies, the extract of P.O showed antinociceptive, anxiolytic and anti inflammation effects in Mice and rats. This study was designed to evaluate different doses of the aqueous extracts of PO on withdrawal syndrome on mice. In this study, 40 male albino mice [25-30 gr] were used. Morphine was used to produce drug dependency by Marshall Method [10 doses of drug in four days]. Different doses of the extract. [25, 50, 75 mg/kg IP] were injected to the separated groups and saline [10 ml/kg-ip] were injected to the one control group 30 min before of noloxone 2 mg/kg. The number of Jumping and amount of weight losses were used for assessment of classic withdrawal syndrome sign. The results indicated that the extract of PO significantly decreased the number of Jumping [p= 0.000] and also weight losses in 25 mg doses of extract [dose-dependent] in mice [p=0.045] It is concluded that the aqueous extract of PO may be play an important role on the modulation of withdrawal syndrome in mice
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Syndrome de sevrage
/
Extraits de plantes
/
Phytothérapie
/
Souris
/
Morphine
/
Naloxone
Limites du sujet:
Animaux
langue:
Persan
Texte intégral:
J. Med. Plants
Année:
2009
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS