Vitamin D receptor gene BSMI polymorphisms in systemic lupus erythematosus and healthy subjects

ABSTRACT

Vitamin D receptor [VDR] gene polymorphisms cause functional differences in immunomodulatory action of vitamin D. An association between VDR gene BSMI polymorphisms and systemic lupus erythematosus [SLE] has been documented. To compare the VDR gene BSMI polymorphisms in patients with SLE and healthy controls. This was a case-control study conducted in the city of Mashhad [Iran]. Sixty patients with lupus from two outpatient rheumatology clinics and 45 non-relative healthy controls of the same sex were selected using the census procedure. VDR gene typing was performed based on polymerase chain reaction-restriction fragment length polymorphism [PCR-RFLP]. The results were analyzed using chi square test while a P < 0.05 was considered as significant. The distribution of VDR genotyping of BSMI polymorphisms in patients with SLE were 23.3% for BB, 60% for Bb and 16.7% for bb. Similarly, the values found for healthy group were 33.3%, 46.7%, and 20% for BB, Bb, and bb, respectively. There was no statistically significant difference between two groups. No significant difference in relative frequency of VDR gene BSMI polymorphisms in SLE patients and healthy individuals was established