Prednisolone as a new approach for treatment of HTLV-1 associated polyneuropathy
Pakistan Journal of Medical Sciences. 2009; 25 (1): 142-145
Dans Anglais
| IMEMR
| ID: emr-92391
ABSTRACT
We have previously shown the implication of HTLV-1 in polyneuropathy in a HTLV-1 endemic area in Mashhad. Treatment with corticosteroids [prednisolone and methylprednisolone] have been recommended for HTLV-1 associated diseases. In the current study we attempted to evaluate the efficiency of prednisolone in HTLV-1 associated polyneuropathy. All recognized cases of HTLV-1 polyneuropathy admitted to Imam Reza Hospital [between 1999-2004] were selected for the study. The other common causes of polyneuropathy were excluded using biochemical, hematological, and neurologic examination. Anti-HTLV1 IgG assays were carried out and positive anti-HTLV-1 results were then confirmed by Western Blot Analyzing. All of the HTLV-1 associated polyneuropathy patients were given prednisolone, 1mg/ kg and tapering 5mg/ per week, for three month. Muscle force and paresthesia of all cases were returned to normal pattern. This therapeutic regimen led to reduction of disease severity. Muscle force increased to V/V and paresthesia of all cases were severely decreased. The results of present study suggest that immunosuppressive treatment is very effective for HTLV-1 associated polyneuropathy patients
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Indice:
Méditerranée orientale
Sujet Principal:
Polyneuropathies
/
Prednisolone
/
Leucémie-lymphome à cellules T de l'adulte
/
Immunosuppresseurs
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Pak. J. Med. Sci.
Année:
2009
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