Propofol induced pain; Comparison between effects of lidocaine propofol mixture and metoclopramide premedication
Professional Medical Journal-Quarterly [The]. 2008; 15 (2): 205-210
Dans Anglais
| IMEMR
| ID: emr-94461
ABSTRACT
Propofol causes pain on injection in 28% - 90% of patients. A number of techniques have been tried for minimizing propofol-induced pain with variable results.To compare the use of premixed lidocaine-propofol with metoclopramide pretreatment for the reduction of pain during injection of propofol in adult patients. A prospective, double blind, randomized, placebo-controlled study. Shiraz University Hospital, Department of Anesthesiology, Shiraz, Iran. From Jan 2007 to Dec 2007. 202 subjects [ASA I-II] scheduled for elective operations under general anesthesia were allocated into three groups and treated as follows Group A 20 ml propofol mixed with 20mg lidocaine%1 following 2ml normal saline; Group B 20 ml propofol mixed with 2ml normal saline following 5 mg metoclopramide; Group C [control group] 20 ml propofol mixed with 2 ml normal saline following 2 ml normal saline. Pain intensity was graded by a single, blinded observer and recorded as either severe, moderate, mild or no pain according to the response of the patients to the injection. The incidence of pain was 72% in placebo group compared to 58.7% in the metoclopramide and 28.8% in the lidocaine group. Propofol-lidocaine admixture is more effective than metoclopramide pre treatment in decreasing the pain of propofol injection
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Indice:
Méditerranée orientale
Sujet Principal:
Douleur
/
Prémédication
/
Essais contrôlés randomisés comme sujet
/
Méthode en double aveugle
/
Études prospectives
/
Résultat thérapeutique
/
Lidocaïne
/
Métoclopramide
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Professional Med. J.-Q
Année:
2008
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