Biodeterioration of sulfaguanidine in visually spoiled tablets by penicillium species

ABSTRACT

The work aims to evaluate the potential role of microorganisms in deteriorating sulfaguanidine tablets already found spoiled as shown by their change in colour. Attempts to isolate microbes resulted in the isolation of three Perdcillium isolates. The role of these isolates in utilizing sulfaguaninine and certain other sulfa compounds supplied to Czapek's liquid medium was attempted. Criteria were mycelial dry weight [mg/100 ml culture and mg/gm sucrose consumed], sulfa consumption and sucrose consumption each in mg/100 ml culture. It was found that sulfaguanidine could be utilized by the isolated penicillii when supplied to Czapek's liquid medium, but not sulfanilamide and the sodium salts of sulfadimidine and sulfacetamide. Utilization of sulfa compounds in the literature by fungi has not been recorded. This gives value for the work it this paper